Early Inhibition of IL-1b Expression by IFN-g Is Mediated by Impaired Binding of NF-kB to the IL-1b Promoter but Is Independent of Nitric Oxide
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms of iNOS induction by IL-1b and IFN-g in rat aortic smooth muscle cells
Teng, Xingwu, Hanfang Zhang, Connie Snead, and John D. Catravas. Molecular mechanisms of iNOS induction by IL-1b and IFN-g in rat aortic smooth muscle cells. Am J Physiol Cell Physiol 282: C144–C152, 2002;—In rat aortic smooth muscle cells (RASMC), interferon (IFN)-g enhanced nitrite accumulation and type II nitric oxide synthase (iNOS) protein expression induced by interleukin (IL)-1b. IFN-g a...
متن کاملEndotoxin-mediated nitric oxide synthesis inhibits IL-1b gene transcription in ANA-1 murine macrophages
Schroeder, Rebecca A., Charles Cai, and Paul C. Kuo. Endotoxin-mediated nitric oxide synthesis inhibits IL-1b gene transcription in ANA-1 murine macrophages. Am. J. Physiol. 277 (Cell Physiol. 46): C523–C530, 1999.—On the basis of previous work demonstrating nitric oxide (NO)mediated inhibition of nuclear factor-kB (NF-kB) DNA binding, we hypothesized that NO downregulates NF-kB-dependent inter...
متن کاملNO Inhibits Cytokine-Induced iNOS Expression and NF-kB Activation by Interfering With Phosphorylation and Degradation of IkB-a
Nitric oxide (NO) is known to have antiatherogenic and anti-inflammatory properties, but its effects on the cytokine-induced nuclear factor-kappa B (NF-kB) activation pathway in relation to the regulation of inducible nitric oxide synthase (iNOS) gene in vascular smooth muscle cells (VSMCs) remain elusive. To elucidate the roles of NO in the regulation of cytokine-induced NF-kB activation and c...
متن کاملHEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Interleukin 1b inhibits interleukin 6–mediated rat g fibrinogen gene expression
Interleukin (IL)-1b and IL-6 are the 2 major inducers of a group of hepatic genes during acute inflammation; however, each cytokine uses different intracellular signaling molecules. In most instances, the 2 cytokines interact positively to enhance hepatic gene expression, but in one class of acute-phase reactants, which includes fibrinogen, IL-1b exerts a transient inhibitory effect over the IL...
متن کاملEarly inhibition of IL-1β expression by IFN-γ is mediated by impaired binding of NF-κB to the IL-1β promoter but is independent of nitric oxide.
The significance of bacterial RNA recognition for initiating innate immune responses against invading pathogens has only recently started to be elucidated. Bacterial RNA is an important trigger of inflammasome activation, resulting in caspase-1-dependent cleavage of pro-IL-1β into the active form. It was reported previously that prolonged treatment with IFN-γ can inhibit IL-1β production at the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2013